VINNO proudly announces a significant advancement in Ultra‑Resolution Microscopy (URM) technology, highlighted by the establishment of nine prospective multicenter clinical studies and the publication of five peer‑reviewed papers in leading international journals.

Building a Global URM Research Network

VINNO URM has now formed one of the most comprehensive multicenter research networks in ultrasound innovation. Partnering with over 180 leading hospitals, these studies are designed to provide large-scale clinical evidence, validate diagnostic accuracy, and accelerate the translation of URM technology into routine clinical practice.

By covering key areas such as oncology, nephrology, and organ transplantation, these multicenter projects aim to:

• Establish objective diagnostic criteria for URM across multiple diseases
• Support early, safe, and noninvasive detection of critical conditions like cancer and chronic kidney disease
• Bridge academic research and clinical application, driving a new era of precision ultrasound

Current URM Multicenter Studies:

1. Aug. 23, 2024: Multicenter Study on Super-Resolution Microscopy Ultrasound Imaging of Breast Masses and Sentinel Lymph Nodes – Ruijin Hospital, 38 hospitals

2. Nov. 15, 2024: Prospective Multicenter Study on Super-Resolution Microscopy Imaging for Differential Diagnosis of Cervical Lymph Nodes – PLA General Hospital (5th Medical Center), 22 hospitals 

3. April. 12, 2025: Prospective Multicenter Study on Super-Resolution Microscopy Imaging for Assessing Benign and Malignant Superficial Lymph Nodes – Peking University Third Hospital, 41 hospitals

4. April. 12, 2025: Multicenter Study on Super-Resolution Microscopy Imaging for Assessing Bladder Tumor Invasion Depth – Peking University Third Hospital & Renji Hospital, 25 hospitals

5. May. 21, 2025: Prospective Multicenter Study on Super-Resolution Microscopy Ultrasound Imaging in Transplanted Kidneys – West China Hospital & First Hospital of China Medical University, 15 hospitals

6. May. 24, 2025: Prospective Multicenter Study on Super-Resolution Microscopy Imaging for Predicting Myometrial Invasion and Biological Behavior in Endometrial Cancer – Shengjing Hospital, 27 hospitals

7. July. 25, 2025: Prospective Multicenter Study on Super-Resolution Microscopy Ultrasound Imaging in Chronic Nephritis – Jiangsu Provincial People’s Hospital, 11 hospitals

8. Aug. 4, 2025: Prospective Multicenter Study on 3D Dynamic Assessment and Recurrence Risk Prediction of Keloids Using Super-Resolution Ultrasound Integrated with Multi-Modal Imaging – China-Japan Friendship Hospital, 5 hospitals

9. Sept. 5, 2025: Ultrasound Microbubble-Assisted Endovascular Thrombectomy for Acute Large Vessel Occlusion Stroke: A Multicenter Randomized Controlled Study (SONIC-EVT) - Second Affiliated Hospital of Army Medical University, 4 hospitals

10. Sept. 19, 2025: Thyroid & Breast Multimodal Ultrasound Multicenter Study- Ruijin Hospital, Shanghai Jiaotong University, 42 hospitals

11. Sept. 19, 2025: Liver Tumor URM Multicenter Study- Ruijin Hospital, Shanghai Jiaotong University, 35 hospitals

Publications

VINNO URM’s clinical value is further validated by five peer‑reviewed papers published in internationally recognized journals, including European Radiology — one of the highest‑impact journals in medical imaging — and the Journal of Ultrasound in Medicine, the official publication of the American Institute of Ultrasound in Medicine (AIUM). These publications highlight URM’s potential to reshape diagnostics across oncology, hepatology, and neuroscience.

1. Feasibility Analysis of Ultra-Resolution Microscopy Based on Contrast-Enhanced Ultrasound (CEUS) in Benign and Malignant Breast Lesions [Sun, P. F., Zhai, L. X., Dong, Y. Y., Hu, X. D., Li, M., Qian, L. X., & Zhao, J. F. (2025). Feasibility analysis of ultra-resolution microscopy based on contrast-enhanced ultrasound (CEUS) in benign and malignant breast lesions. Journal of Ultrasound in Medicine, 44(8), 1437–1446. https://doi.org/10.1002/jum.16699]

2. Multi-modal Ultrafast Sonography Microscopy (MUSM) for Super-Resolution Imaging of Cerebral Vascular Dynamics in a Mouse Model of Hypertension Induced by Angiotensin-II and L-NAME [Wang, B.-Q., Ma, Y.-F., Zhang, G.-Q., Yan, K., Wang, Y.-Y., Zhang, Q., Chen, L., Zhao, C.-H., Lin, S., & Yang, Q.-W. (2024). Multi-modal ultrafast sonography microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME. Brain Hemorrhages. https://doi.org/10.1016/j.hest.2024.11.001]

3. Relationship Between Contrast‑Enhanced Ultrasound Combined with Ultrasound Resolution Microscopy Imaging and Histological Features of Hepatocellular Carcinoma [Wang, F., Yu, J., Lu, X., Numata, K., Ruan, L., Zhang, D., Liu, X., Li, X., Wan, M., Zhang, W., & Zhang, G. (2025). Relationship between contrast-enhanced ultrasound combined with ultrasound resolution microscopy imaging and histological features of hepatocellular carcinoma. Abdominal Radiology (New York), 50(8), 3530–3542. https://doi.org/10.1007/s00261-025-04825-y]

4. Super-Resolution Ultrasound Imaging of Intranodal Lymphatic Sinuses for Predicting Sentinel Lymph Node Metastasis in Breast Cancer: A Preliminary Study [Xia, S., Hua, Q., Song, Y., Yuan, C., Zheng, Y., Tao, R., Xu, J., Cai, E., Zhang, Y., Wu, F., Guo, W., Tian, Y., Dong, Y., & Zhou, J. (2025). Super-resolution ultrasound imaging of intranodal lymphatic sinuses for predicting sentinel lymph node metastasis in breast cancer: A preliminary study. European Radiology. Advance online publication. https://doi.org/10.1007/s00330-025-11520-5]

5. Super-Resolution Ultrasound and Microvasculomics: A Consensus Statement  [Xia, S., Zheng, Y., Hua, Q., Wen, J., Luo, X., Yan, J., Bai, B., Dong, Y., Zhou, J., & Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound. (2024). Super-resolution ultrasound and microvasculomics: A consensus statement. European Radiology, 34(11), 7503–7513. https://doi.org/10.1007/s00330-024-10796-3]

VINNO's Vision

By combining 9 μm-level microvascular visualization with extensive multicenter validation and robust scientific evidence, VINNO URM is reshaping diagnostic pathways — shifting from late-stage treatment to proactive early intervention. This reinforces VINNO’s mission to establish a new global standard in noninvasive, high-resolution imaging. 

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This article will be regularly updated as VINNO URM continues to evolve and achieve new milestones in research and clinical application.

For any inquiries or collaborations related to URM technology, please contact us at marketing@vinno.com.