VINNO proudly announces a significant advancement in Ultra‑Resolution Microscopy (URM) technology, highlighted by the establishment of nine prospective multicenter clinical studies and the publication of five peer‑reviewed papers in leading international journals.

Building a Global URM Research Network

VINNO URM has now formed one of the most comprehensive multicenter research networks in ultrasound innovation. Partnering with over 180 leading hospitals, these studies are designed to provide large-scale clinical evidence, validate diagnostic accuracy, and accelerate the translation of URM technology into routine clinical practice.

By covering key areas such as oncology, nephrology, and organ transplantation, these multicenter projects aim to:

• Establish objective diagnostic criteria for URM across multiple diseases
• Support early, safe, and noninvasive detection of critical conditions like cancer and chronic kidney disease
• Bridge academic research and clinical application, driving a new era of precision ultrasound

Publications

VINNO URM’s clinical value is further validated by five peer‑reviewed papers published in internationally recognized journals, including European Radiology — one of the highest‑impact journals in medical imaging — and the Journal of Ultrasound in Medicine, the official publication of the American Institute of Ultrasound in Medicine (AIUM). These publications highlight URM’s potential to reshape diagnostics across oncology, hepatology, and neuroscience.

1. Feasibility Analysis of Ultra-Resolution Microscopy Based on Contrast-Enhanced Ultrasound (CEUS) in Benign and Malignant Breast Lesions [Sun, P. F., Zhai, L. X., Dong, Y. Y., Hu, X. D., Li, M., Qian, L. X., & Zhao, J. F. (2025). Feasibility analysis of ultra-resolution microscopy based on contrast-enhanced ultrasound (CEUS) in benign and malignant breast lesions. Journal of Ultrasound in Medicine, 44(8), 1437–1446. https://doi.org/10.1002/jum.16699]

2. Multi-modal Ultrafast Sonography Microscopy (MUSM) for Super-Resolution Imaging of Cerebral Vascular Dynamics in a Mouse Model of Hypertension Induced by Angiotensin-II and L-NAME [Wang, B.-Q., Ma, Y.-F., Zhang, G.-Q., Yan, K., Wang, Y.-Y., Zhang, Q., Chen, L., Zhao, C.-H., Lin, S., & Yang, Q.-W. (2024). Multi-modal ultrafast sonography microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME. Brain Hemorrhages. https://doi.org/10.1016/j.hest.2024.11.001]

3. Relationship Between Contrast‑Enhanced Ultrasound Combined with Ultrasound Resolution Microscopy Imaging and Histological Features of Hepatocellular Carcinoma [Wang, F., Yu, J., Lu, X., Numata, K., Ruan, L., Zhang, D., Liu, X., Li, X., Wan, M., Zhang, W., & Zhang, G. (2025). Relationship between contrast-enhanced ultrasound combined with ultrasound resolution microscopy imaging and histological features of hepatocellular carcinoma. Abdominal Radiology (New York), 50(8), 3530–3542. https://doi.org/10.1007/s00261-025-04825-y]

4. Super-Resolution Ultrasound Imaging of Intranodal Lymphatic Sinuses for Predicting Sentinel Lymph Node Metastasis in Breast Cancer: A Preliminary Study [Xia, S., Hua, Q., Song, Y., Yuan, C., Zheng, Y., Tao, R., Xu, J., Cai, E., Zhang, Y., Wu, F., Guo, W., Tian, Y., Dong, Y., & Zhou, J. (2025). Super-resolution ultrasound imaging of intranodal lymphatic sinuses for predicting sentinel lymph node metastasis in breast cancer: A preliminary study. European Radiology. Advance online publication. https://doi.org/10.1007/s00330-025-11520-5]

5. Super-Resolution Ultrasound and Microvasculomics: A Consensus Statement  [Xia, S., Zheng, Y., Hua, Q., Wen, J., Luo, X., Yan, J., Bai, B., Dong, Y., Zhou, J., & Chinese Artificial Intelligence Alliance for Thyroid and Breast Ultrasound. (2024). Super-resolution ultrasound and microvasculomics: A consensus statement. European Radiology, 34(11), 7503–7513. https://doi.org/10.1007/s00330-024-10796-3]

6. Dual-Vessel Microcirculation Imaging in Discriminating Non-Hodgkin Lymphoma Subtypes Using Super-Resolution Ultrasound: An Exploring Study [Dong Y, Hua Q, Xia S, Yuan C, Li C, Song Y, Zheng Y, Tao R, Liu Z, Zhang Y, Wu F, Guo W, Tian Y, Zhou J. Dual-Vessel Microcirculation Imaging in Discriminating Non-Hodgkin Lymphoma Subtypes Using Super-Resolution Ultrasound: An Exploring Study. Acad Radiol. 2025 Oct 28:S1076-6332(25)00971-7. https://doi.org/10.1016/j.acra.2025.10.015]

7. Ultrasound Localization Microscopy for the Assessment of Microvascular Abnormalities in Transplant Renal Artery Stenosis [Li T, Sun H, Gai Y, Zhu L, Yang J, Ma C. Ultrasound Localization Microscopy for the Assessment of Microvascular Abnormalities in Transplant Renal Artery Stenosis. Ultrasound Med Biol. 2025 Nov;51(11):2120 2124. https://doi.org/10.1016/j.ultrasmedbio.2025.07.032]

8. Super-Resolution Ultrasound Imaging of Renal Microcirculation in a Murine Model of Renal Fibrosis [Xu Y, Luo Y, Chen M, Peng Q, Niu C. Super-Resolution Ultrasound Imaging of Renal Microcirculation in a Murine Model of Renal Fibrosis. J Ultrasound Med. 2025 Jul 16. https://doi.org/10.1002/jum.70003]

9. Scanner-Based Rapid Ultrasound Resolution Microvascular Imaging for Noninvasive Assessment of Renal Microcirculation Changes in Rat Acute Kidney Injury [Zhu J, Zhao P, An H, Wang Y, Li Q, Luo Y. Scanner-Based Rapid Ultrasound Resolution Microvascular Imaging for Noninvasive Assessment of Renal Microcirculation Changes in Rat Acute Kidney Injury. Ultrasound in medicine and biology. 2025 Oct 24 https://doi.org/10.1016/j.ultrasmedbio.2025.08.026]

10. Ultrasound super‑resolution microvascular imaging of kidney microvascular alterations in acute kidney injury on a clinical ultrasound scanner [Zhao, P., Zhu, J., An, H. et al. Ultrasound super-resolution microvascular imaging of kidney microvascular alterations in acute kidney injury on a clinical ultrasound scanner. Eur J Med Res 30, 1116 (2025). https://doi.org/10.1186/s40001-025-03278-9]

11. Ultrasound localization microscopy for early detection of acute kidney allograft rejection [Lingxi Zhu, Chunyan Ma, Tan Li, Ultrasound localization microscopy for early detection of acute kidney allograft rejection, Nephrology Dialysis Transplantation, Volume 40, Issue 11, November 2025, Pages 2207–2209,  https://doi.org/10.1093/ndt/gfaf106]

12. Super-Resolution Ultrasound-Based Habitat Imaging: A Consensus Statement [Xia S, Zheng Y, Hua Q, et al. Super-Resolution Ultrasound-Based Habitat Imaging: A Consensus Statement. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(2): 97-102. https://doi.org/10.37015/AUDT.2025.250025]

VINNO's Vision

By combining 9 μm-level microvascular visualization with extensive multicenter validation and robust scientific evidence, VINNO URM is reshaping diagnostic pathways — shifting from late-stage treatment to proactive early intervention. This reinforces VINNO’s mission to establish a new global standard in noninvasive, high-resolution imaging. 

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This article will be regularly updated as VINNO URM continues to evolve and achieve new milestones in research and clinical application.

For any inquiries or collaborations related to URM technology, please contact us at marketing@vinno.com.