Unlocking a New Era in Medical Imaging: What is Ultra-Resolution Microscopy (URM) Technology?

In the world of medical imaging, clarity is everything. The ability to see tiny details in the human body can make the difference between early diagnosis and missed conditions. This is where Ultra-Resolution Microscopy (URM) Technology comes in—a breakthrough that allows doctors to see what was once invisible.

Imagine trying to read a book with fogged-up glasses. Traditional ultrasound technology provides valuable images, but their resolution is limited, making it harder to see the smallest structures in the body, like tiny blood vessels or subtle changes in tissues. URM is like wiping those glasses clean, revealing a level of detail never seen before.

Ultra Resolution Microscopy imaging (URM) is a novel ultrasound imaging technique that primarily relies on contrast microbubbles which can overcome the limitations of traditional ultrasound refraction limitation，allowing for a more detailed depiction of microvascular structure and flow dynamics with  a spatial resolution of tens of micrometers.

URM  firstly captures the echo signals with a very high temporal resolution based on ultrafast software beamforming platform.The MBs (micro bubbles) signal can be effectively separated from the tissue clutter by Singular Value Decomposition (SVD) as the clutter filter.  Then, The Mbs are isolated and localized to individual point by a spatial compression algorithm. The accelerated Mbs tracking algorithm combined with probability and haemodynamics model  was used to track the individual MBs point  , which could achieve a good capture of the motion of MBs with different velocity in a very short time. Finally, the density and velocity information of Mbs can be achieved from the tracked Mbs movement trajectory.

Researchers have successfully applied URM in preclinical animal models and clinical pilot studies, indicating extensive clinical application prospects.

Imaging Process of URM

When it comes to diseases like cancer, heart disease, and organ failure, early detection is key. Many conditions begin with microscopic changes—tiny tumors forming, blood vessels growing abnormally, or organs struggling with reduced blood flow. In the past, these early warning signs were nearly impossible to detect. URM changes that.

By providing ultra-clear visualization of microvascular structures, URM allows doctors to:

• Detect diseases earlier—Spotting small, abnormal growths or vascular changes long before they become serious
• Improve accuracy in diagnosis—Reducing uncertainty in identifying conditions like tumors, organ damage, or circulation disorders
• Minimize invasive procedures—Offering a safer, non-invasive alternative to biopsies and exploratory surgeries

Kidney Transplant

Invasive micropapillary carcinoma

URM-Quantitative Analysis Toolkit (QAT)

URM-QAT is a professional workstation platform developed by VINNO specifically for medical image analysis, primarily designed for quantitative analysis, data management, and research applications in Ultra Resolution Microscopy imaging . The software offers advanced measurement tools for such as blood vessels density, velocity，curvature，complexity level and etc., providing assistance for doctors in accurately evaluating pathological features.

URM-QAT ensures compatibility with VINNO ultrasound systems to enhance clinical diagnostic efficiency. With its user-friendly interface and comprehensive data generation, it is widely used in radiology departments and research institutions, supporting precision diagnoses and clinical studies.

Published Articles List：

[1] Xia S J, Zheng Y H, Hua Q, et al. Super-resolution ultrasound and microvasculomics: a consensus statement[J]. European radiology, 2024, 34(11): 7503-7513.

[2] Wang F, Yu J, Lu X, et al. Relationship between contrast-enhanced ultrasound combined with ultrasound resolution microscopy imaging and histological features of hepatocellular carcinoma[J]. Abdominal Radiology, 2025: 1-13.

[3] Wang B Q, Ma Y F, Zhang G Q, et al. Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME[J]. Brain Hemorrhages, 2024.

[4] Xia S J, Hua Q, Song Y Y, et al. Super-resolution ultrasound imaging of intranodal lymphatic sinuses for predicting sentinel lymph node metastasis in breast cancer: a preliminary study[J]. European Radiology, 2025: 1-10.

[5] Sun P F, Zhai L X, Dong Y Y, et al. Feasibility Analysis of Ultra-Resolution Microscopy Based on Contrast Enhanced Ultrasound (CEUS) in Benign and Malignant Breast Lesions[J]. J Ultrasound Med 2025; 9999:1–10